Headache, common cold or fever. This is a personal preference.

However, here are soft recommendations for common health ailments: Reeder says determining which pain reliever to take is a matter of finding what works best for you. Should I Take Acetaminophen or Ibuprofen? Pamprin uses acetaminophen and asprin in its products. Midol uses ibuprofen, naproxen and acetaminophen in its products. Make sure to check the label before taking over-the-counter painkillers. Aspirin - brand names include Bayer and Ecotrin.Ibuprofen - brand names include Advil and Motrin.Acetaminophen is also included in hundreds of medications including Excedrin, Nyquil, Sudafed, Mucinex and Theraflu. Acetaminophen - brand names include Tylenol.In other words, it reduces inflammation and pain in the body, and it can also be used as a fever reducer,” Reeder says. “Ibuprofen is a non-steroid, anti-inflammatory. Unlike acetaminophen, ibuprofen acts as an anti-inflammatory drug, which means it reduces inflammation and swelling. It’s a good idea to check the labels of all medications, both prescription and over-the-counter, to prevent overdosing. While Tylenol’s only active ingredient is acetaminophen, there are hundreds of other medications that include acetaminophen.

“Tylenol is the brand usually associated with over-the-counter acetaminophen.” “Acetaminophen is a pain reliever and fever reducer,” Reeder says. It’s easy to confuse acetaminophen as an anti-inflammatory drug, but Reeder says it actually isn't meant for that purpose. But, what’s the difference between the two? Jordan Reeder, ARNP, UnityPoint Health, helps you decide which over-the-counter pain reliever is best for your situation. Most of us manage common aches and pains, fevers and other minor health concerns by reaching for acetaminophen or ibuprofen.

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